Both heterozygous and homozygous variants of MTHFR C677T and A1298C associate with the development of varicose veins according to study in EBioMedicine in January 2015.
MTHFR is a gene related to the nutrient folate that’s also tied to cardiac function, detoxification of estrogens and metals, anxiety and depression and more. Nutrition is an important consideration with varicose veins.
Lab testing can identify potential gene problems so you can make appropriate changes to food, supplements, and lifestyle. The use of folate and other nutrients may prevent the varicosities altogether (along with avoiding other potential problems that can occur from this same gene). Your inherited genes don’t change, but you can alter the epigenetic expression of your genes.
The first line of defense I recommend for people with the MTHFR gene variant is to eat a dark green leafy salad every day. In my opinion, prevention is more pleasant than sore legs, vein stripping and support hose.